Giuseppe Valacchi

Bio

Giuseppe Valacchi is David H. Murdock Distinguished Professor and Professor of Regenerative Medicine at NC State University (NCSU). His research is focused on understanding the cellular and molecular redox mechanisms that define the tissues physio-pathological responses to endogenous and exogenous factors (Exposome) with special focus on the skin and the gut-skin axis. He coined the word “OxInflammation” which defines the cross-talk between oxidative stress and inflammation and it is now well accepted and cited in the redox biology community. Recently Dr. Valacchi has also been involved in understanding the altered redox involvement in the pathogenesis of Rett Syndrome and Autism spectrum disorders.

He obtained his B.S. in Physiology,  his M.S. in Physiopathology and his Ph.D. in Cellular Physiology and Neuroimmuno-physiology with Honors from the University of Siena, Italy. During his post-graduate training he spent six years in the United States where he was first post-doc at the University of California, Berkley (UCB) in the laboratory of Prof. Lester Packer, then in the Department of Internal Medicine and the Department of Nutrition at the University of California, Davis (UCD). He became a junior faculty in the Department of Internal Medicine Pulmonary Division (UCD). In 2006, he was awarded the “brain drain project,” granted by the Italian Ministry of Health and returned to Italy at the University of Siena as Assistant Professor. Since 2011 he has been on faculty at the University of Ferrara, first as Associate Professor and then as Full Professor in Physiology. From 2008, he has also served as an adjunct professor at Kyung Hee University, Seoul, South Korea. He joined the Plants for Human Health Institute (NCSU) in 2016.

He is author of over 350 peer reviewed international manuscripts, 20 book chapters, 4 books. He is the President of the Society of Free Radical Research -Europe (SFRR-E) and has been a Council member for SFRR-E from 2017 to 2021.

Editor:
Archives in Biochemistry and Biophysics;
Redox Experimental Medicine;
Review Editor for Frontiers in Neuroscience;
Frontiers in Pharmacology: Inflammation Pharmacology

Associate Editor:
Journal of Traditional and Complementary Medicine;
Frontiers in Cellular Biochemistry;
World Research Journal of Biochemistry;
Mediators of Inflammation

Editorial Board Member:
Scientific Reports;
Antioxidants;
Free Radicals in Biology and Medicine;
Journal of Chemistry;
BioFactors;
Open Biochemistry Journal;
Biomed Research International (Dermatology Subject);
Frontiers in Inflammation Pharmacology;
Genes and Nutrition;
Journal of the Siena Academy of Science

Scientific Advisor Board Member:
Skinceuticals,
NuSkin,
SkinBetterSciences,
EltaMD,
PCA,
VitaPod

H index: 73 (scholar), 60 (Scopus)

Lab Staff

Publications

• Comparing UV and Diesel Cutaneous Damage and Evaluating the Protective Role of a Topical Antioxidant Mixture Containing Vitamin C, E and Ferulic Acid , EXPERIMENTAL DERMATOLOGY (2025)
• Effect of Synthetic Peptides Identified in the Bullfrog Skin on Inflammation and Oxidative Stress Control: An In Vitro Analysis , MOLECULES (2025)
• Gossypin-Loaded Ethosome Gel for Cutaneous Administration: A Preliminary Study on Melanoma Cells , ANTIOXIDANTS (2025)
• In situ forming gels as subcutaneous delivery systems of curcumin and piperine , SCIENTIFIC REPORTS (2025)
• Randomized Phase II Clinical Trial of Sulforaphane in Former Smokers at High Risk for Lung Cancer , CANCER PREVENTION RESEARCH (2025)
• Role of Scavenger Receptor B1 (SR-B1) in Improving Food Benefits for Human Health , ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY (2025)
• ABERRANT NLRP3 INFLAMMASOME RESPONSE IN RETT SYNDROME: FROM EX VIVO TO IN VIVO MODELS FOR INVESTIGATING PATHOGENETIC MECHANISMS AND NEW POTENTIAL THERAPEUTIC STRATEGIES , FREE RADICAL BIOLOGY AND MEDICINE (2024)
• ABNORMAL MITOCHONDRION-NLRP3 INFLAMMASOME CROSSTALK IN THE PATHOPHYSIOLOGY OF AUTISM SPECTRUM DISORDER , FREE RADICAL BIOLOGY AND MEDICINE (2024)
• COMPARISON OF POLLUTANT EFFECTS ON CUTANEOUS INFLAMMASOMES ACTIVATION , FREE RADICAL BIOLOGY AND MEDICINE (2024)
• Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study , JOURNAL OF COSMETIC DERMATOLOGY (2024)