Giuseppe Valacchi

Bio

Dr. Valacchi’s work focuses on evaluating the effect of exogenous and endogenous sources of oxidative stress on target organs, such as skin, GI tract and lung, and the signal pathways involved in the cellular responses to these insults with special focus on epithelial wound healing. In addition he aims to study how new topical approaches (derived from natural and synthetic compounds) can ameliorate wound healing and tissue regeneration in both physiological and pathological situations. In the last 10 years he has also been pursuing research involved in understanding the role of oxidative stress in a rare disease, Rett Syndrome, defined as a neurodevelopment pathology, and in the aging processes and how dietary intervention can improve the clinical feature.

In addition, he is Ordinary Professor of Physiology at the University of Ferrara and International Scholar at Kyung Hee University, Seoul, South Korea. He obtained his BS (Physiology) with Laude, his M.S. in Physiopathology and his Ph.D. in Cellular Physiology and Neuroimmuno-physiology from the University of Siena, Italy. His research has been focused in understanding the cellular and molecular redox mechanisms that defines the tissues physio-pathological responses to endogenous and exogenous factors (Exposome) with special focus on target tissues such as skin and respiratory tract.

He is author of over 300 peer reviewed internationals manuscripts, 20 book chapters, 4 books. He has been member of the SFRR-Europe Council from 2017 to 2023. He is currently the SFRR-Europe President Elect. He has won several awards among them the Entelligence Award from Actelion, the Exposome award, the University of Ferrara Bronze Medal (2020 from the Rector of Ferrara, Prof. Zauli). In 2018 he was awarded with the “Doctorate Honoris Causa” in Biochemistry and Pharmacy from the University of Buenos Aires. In 2019 he was the recipient of the Clinical Research award from the SFRR-E and in 2021, he was awarded, in Rome, as “Paladin of Health” from the Italian Ministry of Public Health and Education. In 2022, he was nominated and awarded the title of “Faculty Scholar” at North Carolina State University, a title that recognizes and rewards emerging academic leaders who demonstrate significant achievement. In 2022 he was named David H. Murdock Distinguished Professor at NC State University.

He is Editor for Archives in Biochemistry and Biophysics and Redox Experimental Medicine; Associate Editor for Oxidative medicine and Cellular Longevity, Mediators of Inflammation, Biomed (dermatology); member of the Editorial board of several international journals including, Free Radicals in Biology and Medicine, Antioxidants, Biofactors, Genes and Nutrition.

Publications

• Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins , FRONTIERS IN NUTRITION (2023)
• Blueberry Supplementation and Skin Health , ANTIOXIDANTS (2023)
• CADMIUM EXPOSURE AFFECTS THE PROGRESSION OF HUMAN METASTATIC MELANOMA BY INDUCING A DEREGULATION OF ANTIOXIDANT CELL RESPONSE , FREE RADICAL BIOLOGY AND MEDICINE (2023)
• CONSTITUTIVE ACTIVATION OF NLRP3 INFLAMMASOME MACHINERY IN EX-VIVO MODELS OF RETT SYNDROME: FROM PATHOGENETIC ROLE TO NEW POTENTIAL THERAPEUTIC TARGET , FREE RADICAL BIOLOGY AND MEDICINE (2023)
• Caffeic acid-loaded lipid nanoparticles as a tool to protect skin against oxidative stress: formulation and evaluation on human skin explants , FREE RADICAL BIOLOGY AND MEDICINE (2023)
• Deregulated NLRP3 inflammasome response due to a constitutive activation of NF-kappa B p65 pro-inflammatory pathway in lymphomonocytes of Rett syndrome patients , FREE RADICAL BIOLOGY AND MEDICINE (2023)
• Development of Spray Dried Spirulina Protein-Berry Pomace Polyphenol Particles to Attenuate Pollution-Induced Skin Damage: A Convergent Food-Beauty Approach , ANTIOXIDANTS (2023)
• Editorial: Cell cycle control as a new therapeutic approach for SARS-CoV-2 infection , FRONTIERS IN PHARMACOLOGY (2023)
• Evaluation of Anti-Oxinflammatory and ACE-Inhibitory Properties of Protein Hydrolysates Obtained from Edible Non-Mulberry Silkworm Pupae (Antheraea assama and Philosomia ricinii) , NUTRIENTS (2023)
• INFLAMMASOMES REGULATION BY ENVIRONMENTAL POLLUTANTS IN HUMAN SKIN , FREE RADICAL BIOLOGY AND MEDICINE (2023)