Title: Associate Professor
Regenerative Medicine
Department of Animal Science
Education:
Ph.D., Cellular physiology and neuroimmunophysiology, University of Siena, Siena, Italy
B.S., Physiopathology, University of Siena, Siena, Italy
Phone: 704-250-5433
Lab Personnel:
Francesca Ferrara, Visiting Scholar
Alessandra Pecorelli, Postdoctoral Scholar
Brittany Woodby, Postdoctoral Scholar
Erika Pambianchi, Graduate Student
Dr. Valacchi has been interested in evaluating the effect of exogenous and endogenous sources of oxidative stress on target organs, such as skin and lung, and the signal pathways involved in the cellular responses to these insults with special focus on epithelial wound healing. In addition he aims to study how new topical approaches (derived from natural compounds) can ameliorate wound healing and tissue regeneration in both physiological and pathological situations. In the last eight years he has also been pursuing research involved with understanding the role of oxidative stress in a rare disease, Rett Syndrome, defined as a neurodevelopment pathology, and in the aging processes and how dietary intervention can improve the clinical feature.
Valacchi is a member of the SFRR Europe Council and he is author of more than 170 peer-reviewed international papers, 15 book chapters, one book with H index of 40 and more than 4,000 citations. He has been an invited speaker to more than 80 international conferences and served as organizer/chair to more than 50 international conferences. He has been grant reviewer for the Ministry of Heath in CZ, France, England, Cina, and for the FAMRI association (American Federal Panel). He has won several awards, among them the Entelligence Award from Actelion, OCC Young Investigator Award, Science and Education Award. He is the Associate Editor for the Journal Mediators of Inflammation, Frontiers in Cellular Biochemistry, World Research Journal of Biochemistry and Biomed Research International (Dermatology Subjects), Oxidative Medicine and Cellular Longevity. In addition, he is part of the Editorial Board of several international journals including Genes and Nutrition, Open Biochemistry Journal, Journal of Complementary and Traditional Medicine, and Frontiers in Inflammation Pharmacology.
Publications
- Impact of air pollutants on cutaneous responses in both healthy and compromised skin barrier, and innovative solutions to protect skin against urban pollution, 2017
- Non-conventional rottlerin anticancer properties, 2018
- Influences of the vehicle in the spreading and release of betamethasone, 2018
- Low-grade systemic inflammation is associated with functional disability in elderly people affected by dementia, 2018
- The Association Between Sleeping Time and Metabolic Syndrome Features, Among Older Adults Living in Mediterranean Region: The MEDIS Study, 2018
- Anti-Inflammatory Nutrition and Successful Ageing in Elderly Individuals: The Multinational MEDIS Study, 2018
- ROLE OF NRF2 IN PREVENTING OXIDATIVE STRESS INDUCED CHLORIDE CURRENT ALTERATION IN HUMAN LUNG CELLS, 2017
- Association between Siesta (Daytime Sleep), Dietary Patterns and the Presence of Metabolic Syndrome in Elderly Living in Mediterranean Area (Medis Study): The Moderating Effect of Gender, 2017
- Novel Artificial Tears Containing Cross-Linked Hyaluronic Acid: An In Vitro Re-Epithelialization Study, 2017
- Lactonase Activity and Lipoprotein-Phospholipase A2 as Possible Novel Serum Biomarkers for the Differential Diagnosis of Autism Spectrum Disorders and Rett Syndrome: Results from a Pilot Study, 2017
- Resveratrol: from diet to topical usage, 2017
- Paraoxonase, arylesterase and lactonase activities of paraoxonase-1 (PON1) in obese and severely obese women, 2017
- Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure, 2017
- Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs “in vitro” wound closure, 2017
- Nanostructured lipid systems modified with waste material of propolis for wound healing: Design, in vitro and in vivo evaluation, 2017
- First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents, 2017
- Retention of Mitochondria in Mature Human Red Blood Cells as the Result of Autophagy Impairment in Rett Syndrome, 2017
- P 080 – Effect of ozone oxidative stress on chloride current in human lung cells: Chemical mediators and protective role of catalase, 2017
- Circadian clock as possible protective mechanism to pollution induced keratinocytes damage, 2017
- Modulation of chloride currents in human lung epithelial cells exposed to exogenous oxidative stress, 2017
- Air particulate matter as enhancer of ozone-induced skin damage, 2017
- Circadian clock as possible protective mechanism to pollution induced skin damage, 2017
- Serum from patients affected by Alzheimer disease shows a paraoxonase-dependent pro-apoptotic effect on endothelial cells, 2017
- Nrf2-pathway alteration in RTT syndrome, 2017
- A correlation between redox imbalance and altered mitochondrial quality control pathway in Autistic Spectrum Disorder, 2017
- Modulation of oxidative stress response in neurodevelopment disorders. The case of the Rett syndrome variants: MECP2 and CDKL5, 2017
- Scavenger receptor B1, a cutaneous sensor of pollution-induced oxidative damage, 2017
- First Dual AK/GSK-3β Allosteric Inhibitors Endowed with Antioxidant Properties as Multifunctional, Potential Neuroprotective Agents., 2017
- Protective Effects of Topical Vitamin C Compound Mixtures against Ozone-Induced Damage in Human Skin, 2017
- Monoolein aqueous dispersions as a delivery system for quercetin, 2017
- Adherence to Mediterranean diet; not olive oil consumption alone predicts hypercholesterolemia in elderly: the MEDIS study, 2017
- Residential altitude and fish consumption: Effect on systolic blood pressure in elderly: MEDIS study cross-sectional results, 2017
- protective effects of topical vitamin C compound mixtures against ozone-induced damage in human skin, 2017
- Mediterranean lifestyle and cardiovascular disease prevention, 2017
- Cutaneous Responses to Tropospheric Ozone Exposure, 2017
- NRF2 activation is involved in preventing oxidative stress (OS) induced chloride current alteration in human lung cells, 2017
- Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment, 2017
- Is car use related with successful aging of older adults? Results from the multinational Mediterranean islands study, 2017
- Is parental longevity associated with the cardiovascular risk and the successful aging of their offspring? Results from the multinational MEDIS study, 2017
- Hydrostatic pressure regulates microRNA expression levels in osteoarthritic chondrocyte cultures via the Wnt/β-catenin pathway, 2017
- 4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation, 2017
- Nanostructured lipid carriers (NLC) for the delivery of natural molecules with antimicrobial activity: production, characterisation and in vitro studies, 2017
- SRB1 as a new redox target of cigarette smoke in human sebocytes, 2017
- The Impact of the Financial Crisis on Lifestyle Health Determinants Among Older Adults Living in the Mediterranean Region: The Multinational MEDIS Study (2005-2015), 2017
- Proteomic analysis of 4-hydroxynonenal and nitrotyrosine modified proteins in RTT fibroblasts, 2016
- Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases, 2016
- Redox regulation of inflammatory processes, 2016
- Decrease Paraoxonase-1 (PON-1) Activities in Neurodegenerative Diseases, 2016
- Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing, 2016
- Skeletal muscle mass and body fat in relation to successful ageing of older adults: the multi-national MEDIS study, 2016
- Association between circulatory levels of adipokines and bone mineral density in postmenopausal women, 2016
- Ozone mediators effect on “in vitro” scratch wound closure, 2016
- Comparison of PBMCs morphology and serum cytokines profile between Rett and autistic patients, 2016
- Brain SRB1 modulation as a possible player in Rett syndrome pathogenesis, 2016
- Oxidative stress and physical exercise: effects of training intervention on oxidative stress levels caused by endogenous and exogenous sources, 2016
- Targeted lipidomics distinguishes patient subgroups in mild cognitive impairment (MCI) and late onset Alzheimer’s disease (LOAD), 2016
- Ozone-induced damage in 3D-skin model is prevented by topical vitamin C and vitamin E compound mixtures application, 2016
- Antitubulinic effect of New Fluorazone Derivatives on Melanoma Cells, 2016
- Successful aging among elders living in the Mani continental region vs. insular areas of the Mediterranean: the MEDIS study, 2016
- Antioxidant mixtures protect against ozone induced damage in human reconstructed skin model, 2016
- Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome, 2016
- Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress, 2016
- Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity, 2016
- Tropospheric ozone effects on chlorine current in lung epithelial cells: an electrophysiological approach, 2016
- Early involvement of systemic redox imbalance in late Alzheimer’s Disease and vascular dementia, 2016
- Brain and serum cholesterol metabolism during perimenopausal transition: a risk factor for Alzheimer’s disease?, 2016
- SR-B1 as a new redox target of cigarette smoke in human sebocytes, 2016
- Potassium Ascorbate with ribose–promising therapeutical approach for malignant melanoma, 2016
- Ambient air pollution and emergency department visits for skin conditions, 2016
- Decreased arylesterase activity of paraoxonase-1 (PON-1): common denominator of neuroinflammatory and neurodegenerative diseases, 2016
- Ozone: a multifaceted molecule with unexpected therapeutic activity, 2016
- Acute lithiasic cholecystitis in Rett syndrome: discussion on a complication, 2016
- Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients, 2016
- Oxidative challenge in Alzheimer’s disease: state of knowledge and future needs, 2016