Giuseppe Valacchi

Bio

Dr. Valacchi’s work focuses on evaluating the effect of exogenous and endogenous sources of oxidative stress on target organs, such as skin, GI tract and lung, and the signal pathways involved in the cellular responses to these insults with special focus on epithelial wound healing. In addition he aims to study how new topical approaches (derived from natural and synthetic compounds) can ameliorate wound healing and tissue regeneration in both physiological and pathological situations. In the last 10 years he has also been pursuing research involved in understanding the role of oxidative stress in a rare disease, Rett Syndrome, defined as a neurodevelopment pathology, and in the aging processes and how dietary intervention can improve the clinical feature.

In addition, he is Ordinary Professor of Physiology at the University of Ferrara and International Scholar at Kyung Hee University, Seoul, South Korea. He obtained his BS (Physiology) with Laude, his M.S. in Physiopathology and his Ph.D. in Cellular Physiology and Neuroimmuno-physiology from the University of Siena, Italy. His research has been focused in understanding the cellular and molecular redox mechanisms that defines the tissues physio-pathological responses to endogenous and exogenous factors (Exposome) with special focus on target tissues such as skin and respiratory tract.

He is author of over 300 peer reviewed internationals manuscripts, 20 book chapters, 4 books. He has been member of the SFRR-Europe Council from 2017 to 2023. He is currently the SFRR-Europe President Elect. He has won several awards among them the Entelligence Award from Actelion, the Exposome award, the University of Ferrara Bronze Medal (2020 from the Rector of Ferrara, Prof. Zauli). In 2018 he was awarded with the “Doctorate Honoris Causa” in Biochemistry and Pharmacy from the University of Buenos Aires. In 2019 he was the recipient of the Clinical Research award from the SFRR-E and in 2021, he was awarded, in Rome, as “Paladin of Health” from the Italian Ministry of Public Health and Education. In 2022, he was nominated and awarded the title of “Faculty Scholar” at North Carolina State University, a title that recognizes and rewards emerging academic leaders who demonstrate significant achievement. In 2022 he was named David H. Murdock Distinguished Professor at NC State University.

He is Editor for Archives in Biochemistry and Biophysics and Redox Experimental Medicine; Associate Editor for Oxidative medicine and Cellular Longevity, Mediators of Inflammation, Biomed (dermatology); member of the Editorial board of several international journals including, Free Radicals in Biology and Medicine, Antioxidants, Biofactors, Genes and Nutrition.

Publications

• ABERRANT NLRP3 INFLAMMASOME RESPONSE IN RETT SYNDROME: FROM EX VIVO TO IN VIVO MODELS FOR INVESTIGATING PATHOGENETIC MECHANISMS AND NEW POTENTIAL THERAPEUTIC STRATEGIES , FREE RADICAL BIOLOGY AND MEDICINE (2024)
• ABNORMAL MITOCHONDRION-NLRP3 INFLAMMASOME CROSSTALK IN THE PATHOPHYSIOLOGY OF AUTISM SPECTRUM DISORDER , FREE RADICAL BIOLOGY AND MEDICINE (2024)
• COMPARISON OF POLLUTANT EFFECTS ON CUTANEOUS INFLAMMASOMES ACTIVATION , FREE RADICAL BIOLOGY AND MEDICINE (2024)
• Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study , JOURNAL OF COSMETIC DERMATOLOGY (2024)
• Cutaneous Redox Senescence , BIOMEDICINES (2024)
• Design of a hybrid nanoscaled skin photoprotector by boosting the antioxidant properties of food waste-derived lignin through molecular combination with TiO₂ nanoparticles , INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)
• Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells , CELLS (2024)
• Ethosomes for Curcumin and Piperine Cutaneous Delivery to Prevent Environmental-Stressor-Induced Skin Damage , ANTIOXIDANTS (2024)
• FIRST EVIDENCE OF REDOX DAMAGE BY INDOOR POLLUTION IN LUNG TISSUE BY THE USE OF 2D AND 3D MODELS , FREE RADICAL BIOLOGY AND MEDICINE (2024)
• Feeding the Body Through the Skin: Ethosomes and Transethosomes as a New Topical Delivery System for Bioactive Compounds , ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY (2024)