Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs “in vitro” wound closure

Full Title: Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs “in vitro” wound closure

Journal: Mechanisms of Aging and Development

Year of Publication: 2017

PHHI Author(s): Giuseppe Valacchi
Publication Author(s): Muresan XM, Sticozzi C, Belmonte G, Savelli V, Evelson P, Valacchi G

Abstract:

Scavenger receptor B1 (SR-B1) is a trans-membrane protein, involved in tissue reverse cholesterol transport. Several studies have demonstrated that SR-B1 is also implicated in other physiological processes, such as bacteria and apoptotic cells recognition and regulation of intracellular tocopherol and carotenoids levels. Among the tissues where it is localized, SR-B1 has been shown to be significantly expressed in human epidermis. Our group has demonstrated that SR-B1 levels are down-regulated in human cultured keratinocytes by environmental stressors, such as cigarette smoke, via cellular redox imbalance. Our present study aimed to investigate whether such down-regulation was confirmed in a 3D skin model and under other environmental challengers such as particulate matter and ozone. We also investigated the association between oxidation-induced SR-B1 modulation and impaired wound closure. The data obtained showed that not only cigarette, but also the other environmental stressors reduced SR-B1 expression in epidermal cutaneous tissues and that this effect might be involved in impaired wound healing

Link to Article: https://www.ncbi.nlm.nih.gov/pubmed/29102450