Influences of the vehicle in the spreading and release of betamethasone

Full Title: Influences of the vehicle in the spreading and release of betamethasone

Journal: Therapeutic delivery

Year of Publication: 2018

PHHI Author(s): Giuseppe Valacchi
Publication Author(s): Sonia Molesini, Federica Urto, Alexandra D Cvetkovska, Vincenzo Bettoli, Giuseppe Valacchi, Alessandra Pecorelli, Stefano Manfredini, Silvia Vertuani

Abstract:

AIM:

We compared the performances of two different commercial products both based on betamethasone and an antibiotic but using different pharmaceutical vehicles: a polymer and lipid-enriched cream and a conventional oil-in-water emulsion.

METHODOLOGY:

Evaluation was conducted on a reconstructed human epidermis model. Moreover, skin barrier properties and cutaneous hydration of the two vehicles were evaluated on 20 human healthy volunteers.

RESULTS:

Overall, the polymer and lipid-enriched formulation works as a film-forming product that retains the therapeutic agent for a long time, ensuring its penetration and absorption through the skin, and promoting skin hydration.

CONCLUSION:

The above characteristics are useful in the clinical setting, especially in the context of eczematous diseases with a strong xerotic component.

Link to Article: https://www.ncbi.nlm.nih.gov/pubmed/29424289