Full Title: Influences of the vehicle in the spreading and release of betamethasone
Journal: Therapeutic delivery
Year of Publication: 2018
Publication Author(s): Sonia Molesini, Federica Urto, Alexandra D Cvetkovska, Vincenzo Bettoli, Giuseppe Valacchi, Alessandra Pecorelli, Stefano Manfredini, Silvia Vertuani
We compared the performances of two different commercial products both based on betamethasone and an antibiotic but using different pharmaceutical vehicles: a polymer and lipid-enriched cream and a conventional oil-in-water emulsion.
Evaluation was conducted on a reconstructed human epidermis model. Moreover, skin barrier properties and cutaneous hydration of the two vehicles were evaluated on 20 human healthy volunteers.
Overall, the polymer and lipid-enriched formulation works as a film-forming product that retains the therapeutic agent for a long time, ensuring its penetration and absorption through the skin, and promoting skin hydration.
The above characteristics are useful in the clinical setting, especially in the context of eczematous diseases with a strong xerotic component.
Link to Article: https://www.ncbi.nlm.nih.gov/pubmed/29424289