Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C.Presl ) Baill

Full Title: Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C.Presl ) Baill

Journal: Phytochemistry

Year of Publication: 2013

PHHI Author(s): Mary Grace Mary Ann Lila
Publication Author(s): Graziose, Rocky, Mary H. Grace, Thirumurugan Rathinasabapathy, Patricio Rojas-Silva, Carmen Dekock, Alexander Poulev, Mary Ann Lila, Peter Smith, Ilya Raskin

Abstract:

The traditionally used antimalarial plant, Datisca glomerata (C.Presl) Baill., was subjected to antiplasmodial assay guided fractionation. This led to the isolation of seven new cucurbitacin glycosides, datiscosides I-O, along with the two known compounds, datiscoside and datiscoside B, from the aerial parts of D. glomerata. Their structures and relative stereochemistry were determined on the basis of mass spectrometry, 1D and 2D NMR. Antiplasmodial IC50 values were determined for all isolated compounds, which were also evaluated in vitro for their ability to inhibit Leishmania tarentoleae. The antiplasmodial activity of the compounds was moderate, and ranged from 33.3µM to 7.7µM. None of the compounds showed appreciable antileishmanial activity.

Link to Article: http://www.sciencedirect.com/science/article/pii/S0031942212005201