Associate Professor, Pharmacogenomics, Department of Food, Bioprocessing and Nutrition Sciences
Ph.D., Rutgers University
M.S., Kyiv Shevchenko University, Ukraine
B.S., Kyiv Shevchenko University, Ukraine
More information about Slavko Komarnytsky
- Molecular controls linking inflammation to diabetes. We are dissecting the signaling pathways and transcriptional mechanisms that mediate chronic inflammation and associated risk of diabetes. This allows us to define the mode of action of novel bioactive molecules to improve glucose metabolism and glycemic control through analyses of target gene and protein interactions, microbiome profiles, preclinical animal models, and early phase clinical studies.
- Phenotypical screening in cell culture. We lead discovery of novel bioactives and understanding gene function within the context of energy metabolism in conventional animal and human cell cultures with potential applications for pharmaceutical, food, and cosmetics industries. This also allows us to develop new genetic tools to directly map human health to plant genomes.
- Establishment of structure-activity relationships of plant metabolites and health quality of fruits, vegetables, and industrial hemp (Cannabis). We determine biological activities of parent plant molecules (phenolics, cannabinoids) and their breakdown metabolites to identify dietary constituents with maximum potential benefits to public health. These findings are critical to advance current agricultural, breeding, and genetic approaches to produce better crops.
- Discovery and scientific validation of traditional ethnic medicines. We are dedicated to incorporating traditional medicinal knowledge into modern healthcare and ensuring it meets current safety and efficacy standards, in part by directing the Mobile Discovery program. We are also exploring microbes of diverse habitats and unique environments for discovery of novel metabolites.