Mary Grace

Mary Grace_NC State Plants for Human Health Institute
Senior Researcher
Department of Food, Bioprocessing and Nutrition Sciences

Ph.D., Cairo University

Dr. Mary Grace works in the lab of Dr. Mary Ann Lila. She is involved with the investigation of bioactive components in fruits, vegetables and medicinal herbs. There are three components to her research:

  • Natural products chemistry including isolation, characterization and structural elucidation of secondary metabolites from plants and other natural sources.
  • Biological evaluation of those active natural substances for their potency to alleviate symptoms of some acute and chronic diseases, such as metabolic syndrome, diabetes, age-related diseases, malaria and cancer.
  • Development of analytical techniques for medicinal plant analysis.


Plundrich, N., Grace, M.H., Raskin, I. and Lila, M.A. 2013. Bioactive polyphenols from muscadine grape and blackcurrant stably concentrated onto protein-rich matrices for topical applications. International Journal of Cosmetic Science (Epub ahead of print).

Graziose, R, Rathinasabapathy, T, Lategan, C, Poulev, A, Smith, PJ, Grace, MH, Lila, MA, Raskin, I. Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L. Journal of Ethnopharmacology 2011; 133: 26-30.

Mun, JG,  Grannan, MD, Lachcik, PJ, Rogers, RB, Yousef, GG, Grace, MH, Janle, EM, Li, WQ, Simon, JE, Weaver, CM, Lila MA. Tracking deposition of a 14C-radiolabeled kudzu hairy root-derived isoflavone-rich fraction into bone. Experimental Biology and Medicine 2010; 235: 1224-1235 .

Grace, MH, Lategan, C, Mbeunkui, F, Graziose, R, Smith, PJ, Raskin, I, Lila, MA.  Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana. Natural Product Communications 2010;  5 (12), 1869-1872.

Grace M H., Yousef GG, Kurmukov AG, Raskin I, Lila MA Phytochemical characterization of an adaptogenic preparation from Rhodiola heterodonta. Natural Product Communications 2009; 4: 1-6.

Grace M, Ribnicky D, Kuhn P, Poulev A, Longendra S, Yousef GG, Raskin I, Lila MA. Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine 2009; 16:406-415.

Grace MH, Wilson GR, Kandil FE, Dimitriadis E, Coates RM. Characteristic Flavonoids from Acacia burkittii and Acacia acuminata heartwoods and their differential cytotoxicity to normal and leukemia cells. Natural  Product  Communications 2009; 4, 69-76.

Cheng, DM, Yousef, GG, Grace, MH, Rogers, RB, Gorelick-Feldman J, Raskin I, Lila MA. In vitro production of phytoecdysteroids from Ajuga turkestanica. Plant Cell, Tissue & Organ Culture 2008; 93: 73-83.

Grace MH, Cheng DM, Raskin I, Lila MA. Neo-Clerodane diterpenes from Ajuga turkestanica. Phytochemistry Letters 2008; 1: 81-84.

Grace MH, Faraldos JA, Lila MA, Coates RM, ent-Beyerane diterpenoids from the heartwood of Excoecaria parvifolia. Phytochemistry  2007; 68: 546-553.

Suiero L, Yousef GG, Seigler D, Gonzalez de Mejia E, Grace MH, Lila MA. Chemopreventive potential of flavonoid extracts from plantation-bred and wild Aronia melanocarpa (Black Chokeberry) Fruits. J. Food Science 2006; 71: 480-488.

Yousef GG, Grace MH, Cheng D, Belolipov IV, Raskin I, Lila MA. Comparative phytochemical characterization of three Rhodiola species. Phytochemistry 2006; 67: 2380-2391.

Grace MH, Jin Y, Wilson G, Coates R. New pimarane-derived diterpenes from Petalostigma pubescens and their cytotoxicity. Phytochemistry 2006; 67: 1708-1715.

Khatab, AM, Haggag, EG, Grace, MH. Cytotoxic investigation of Cynara sibthorpiana. Asian Journal of Chemistry, 2006; 18: 423-424.

Kandil FE, Grace MH, Seigler DS, Cheeseman JM. Polyphenolics in Rhizophora mangle L. leaves and their changes during leaf development and senescence. Trees 2004; 18: 518-528.

Grace MH. Chemical composition and biological activity of the volatiles of Anthemis melampodina and Pluchea dioscoridis.  Phytother Res. 2002; 16: 183-185.

Kandil FE, Grace MH. Polyphenols from Cornulaca monacantha. Phytochemistry 2001; 58: 611-613.

Ahmed, AA, Khattab, AM, Grace, MH, Sahl, MM. A new eudesmanolide from Crataegus flava fruits, Fitoterapia 2001; 72: 756-759.

Grace, MH, Nofel, SM,. Pharmaco-chemical investigations of Plantago ovata aerial parts. Bull Fac. Pharm. Cairo Univ. 2001; 39: 357-374.

Grace, MH, Mohamed, TK, Khattab, AM,. Flavonoids of Carduncellus eriocephalus, Egypt. J. Pharm. Sci. 1998; 39: 409-416.

Grace, MH, Khattab, AM. Chemical constituents and molluscicidal activity of Senecio cineraria. Egypt. J. Pharm. Sci. 1998; 39: 253-266.

Grace, M.H, Saleh MM.  Hepato-protective effect of daturaolone isolated from Solanum arundo. Pharmazie 1996; 51: 593-595.

Saleh, MM, Hashem FA, Grace MH. Volatile oil of Egyptian Sweet fennel (Foeniculum vulgare var. dulce, Alef.) and its effects on isolated smooth muscles.  Pharm. Pharmacol. Let. 1996; 6: 5-7.

Saleh, MM, Grace, M, Ismail, BR. Natural Microbial Inhibitors from Brown Alga Petalonia fascia (Muller) Kuntze. Egypt. J. Phytopathol. 1996; 24: 37-43.

Mahran, GH, Saleh, MM, El-Sherei, MM, Grace, MH. Inhibitory effects of different extracts and isolated components from Petalonia fascia (Muller) Kuntze on HIV reverse transcriptase. Bull Fac Pharm. Cairo Univ. 1994; 32: 415-18.

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